Titia de Lange

Titia de Lange has made fundamental discoveries about chromosome structure and DNA repair—work that has led her to conduct a series of investigations aimed at improving breast cancer diagnosis and therapy. Recently, for example, Dr. de Lange began a study of DCIS, an early-stage, noninvasive form of breast cancer for which 50,000 women in the U.S. are treated each year.

One goal is to be able to reliably identify the 30 percent of DCIS patients who are likely to progress to more invasive types of breast cancer, thereby encouraging them to seek appropriate treatment while allowing the other 70 percent, with less aggressive disease, to avoid debilitating therapies they do not need.

Widely recognized for her work on telomeres and breast cancer, Dr. de Lange is an American Cancer Society Professor and the recipient of ongoing support from The Breast Cancer Research Foundation. She has been elected to the National Academy of Sciences and its Institute of Medicine.

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